Yes, you can. Since our backup is based on rsync, you can use rsync filters to exclude files and directories.
How to exclude files or directories
To exclude a directory, place a file called .rsync-filter in the directory, with the following contents:
+ .rsync-filter - *
If you need to exclude certain files, for example, compressed logs from /var/log, place a file called .rsync-filter in /var/log:
You can find more examples on the rsync manual page, under the FILTER RULES section.
Example of excluding files
You could also place the .rsync-filter in root folder and exclude files from there.
+ .rsync-filter - /home/USER/Folder